SCORPION VENOM


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Scorpion venom' attacks tumours
Words
MRI scan of brain
Gliomas are a particularly aggressive form of brain tumour
Researchers have developed a "man-made" scorpion venom to be used in the treatment of brain tumours.

The venom is used as a carrier to deliver radioactive iodine into tumour cells left behind after surgery has removed the bulk of the tumour.

So far the technique has been tested in 18 patients and further trials are under way, a report in the Journal of Clinical Oncology says.

Initial findings suggest the treatment is well-tolerated and may be effective. 

Gliomas are a particularly aggressive form of brain tumours, with only 8% of patients surviving two years and 3% surviving five years from the time of diagnosis.




scorpion scorpion
venom venin
to attack attaquer
tumour (-s) tumeur
treatment traitement
brain cerveau
carrier porteur
to deliver délivrer, amener
iodine teinture d'iode
cell (-s) cellule
left behind subsistant
surgery opération chirurchicale
to remove ôter, enlever
bulk masse
so far pour l'instant
trial (-s) essai
under way en cours de réalisation
further supplémentaire
finding (-s) découverte
to suggest suggérer
well-tolerated bien toléré
effective efficace
aggressive agressif

Despite advances in surgery, radiotherapy and chemotherapy, there has been little improvement in length of survival for patients with gliomas.

Researchers at Cedars-Sinai Medical Center, in California, carried out a study using TM-601, a synthetic version of a peptide, that naturally occurs in the venom of the Giant Yellow Israeli scorpion.

Unlike many substances, the peptide can pass through the bloodstream into the brain and can bind to glioma cells.
We may be able to use it in conjunction with other treatments, such as chemotherapy
Study leader, Dr Adam Mamelak

Patients in the study first had surgery to remove their tumour.

Then 14 to 28 days later, a single, low dose of TM-601 with radioactive iodine attached was injected into the cavity from which the tumour had been removed.

Six patients were given additional doses of the drug.

The main reason for the trial was to check tolerance of the dose and the researchers said there were very few adverse effects.

Median length of survival for all patients was 27 weeks, but two patients had no evidence of tumour and were still alive 33 and 35 months after surgery.


despite en dépit de
advance (-s) avances
surgery chirurgie
radiotherapy radiothérapie
chemotherapy chimiotherapie
improvement amélioration
length of survival durée de survie
patient (-s) with malade de
to carry out réaliser
study étude
to occur apparaître
unlike contrairement à
to pass through pénétrer
bloodstream flux sanguin
to bind to se fixer sur
later plus tard
single seul, unique
low faible
dose dose
attached associé à
to inject injecter
cavity cavité
drug drogue
trial essai, tentative
main reason raison principale
to check vérifier
tolerance tolérance
adverse effect (-s) effets négatifs
median moyen
alive en vie
evidence preuve

Tumour specific

Analysis showed that the most of the radioactivity delivered by the drug had disappeared after 24 hours.

Any radiation that was left was localised to the tumour cavity, suggesting the drug was binding to the tumour cells rather than normal brain cells.

The drug also binds to other types of tumours and the researchers are planning further studies.

Study leader Dr Adam Mamelak, a neurosurgeon at Cedars-Sinai Medical Center, said: "We're using TM-601 primarily as a carrier to transport radioactive iodine to glioma cells, although there are data to suggest that it may also slow down the growth of tumour cells.

"If studies continue to confirm this, we may be able to use it in conjunction with other treatments, such as chemotherapy, because there may be a synergistic effect."

Ed Yong, cancer information officer at Cancer Research UK, said: "Treating brain cancers with radioactive scorpion venom sounds like science fiction.

"But this preliminary study shows that this approach is safe and has potential. Now, larger trials are needed to work out how effective it is.

"This study highlights the varied and ingenious approaches that scientists are using to improve cancer treatments."

the most of l'essentiel de
to be left rester
to localise/localize localiser
to plan prévoir
study leader chef de projet
neurosurgeon chirurgien en neurologie
primarily d'abord
to slow down ralentir
growth croissance
tumor cell (-s) cellule cancéreuse
in conjunction with conjointement avec
synergistic synergétique
effect effet
information officer chargé de l'information
to treat traiter
preliminary préliminaie
approach approche
safe sûr
to have potential avoir du potentiel
large vaste, étendu
to be needed être nécessaire
to work out établir
to highlight éclairer
varied varié
ingenious ingénieux