Gliomas are a
particularly
aggressive form of brain tumour
|
Researchers have developed a "man-made"
scorpion venom
to be used in the treatment of brain tumours.
The venom is used as a
carrier to deliver
radioactive
iodine into tumour cells left behind after surgery has removed the bulk
of the tumour.
So far the technique has been
tested in
18 patients and
further trials are under way, a report in the Journal of Clinical
Oncology says.
Initial findings suggest the
treatment is
well-tolerated and may be effective.
Gliomas are a particularly
aggressive
form of brain
tumours, with only 8% of patients surviving two years and 3% surviving
five years from the time of diagnosis.
|
|
scorpion |
scorpion |
|
venom |
venin |
to |
attack |
attaquer |
|
tumour (-s) |
tumeur |
|
treatment |
traitement |
|
brain |
cerveau |
|
carrier |
porteur |
to |
deliver |
délivrer, amener |
|
iodine |
teinture d'iode |
|
cell (-s) |
cellule |
|
left behind |
subsistant |
|
surgery |
opération chirurchicale |
to |
remove |
ôter, enlever |
|
bulk |
masse |
|
so far |
pour l'instant |
|
trial (-s) |
essai |
|
under way |
en cours de réalisation |
|
further |
supplémentaire |
|
finding (-s) |
découverte |
to |
suggest |
suggérer |
|
well-tolerated |
bien toléré |
|
effective |
efficace |
|
aggressive |
agressif |
|
|
|
|
Despite advances in surgery,
radiotherapy
and
chemotherapy, there has been little improvement in length of survival
for patients with gliomas.
Researchers at Cedars-Sinai
Medical
Center, in
California, carried out a study using TM-601, a synthetic version of a
peptide, that naturally occurs in the venom of the Giant Yellow Israeli
scorpion.
Unlike many substances, the
peptide can
pass through the bloodstream into the brain and can bind to glioma
cells.
Patients in the study first
had surgery
to remove their tumour.
Then 14 to 28 days later, a
single, low
dose of TM-601
with radioactive iodine attached was injected into the cavity from
which the tumour had been removed.
Six patients were given
additional doses
of the drug.
The main reason for the trial
was to
check tolerance of the dose and the researchers said there were very
few adverse effects.
Median length of survival for
all
patients was 27 weeks,
but two patients had no evidence of tumour and were still alive 33 and
35 months after surgery.
|
|
despite |
en dépit de |
|
advance (-s) |
avances |
|
surgery |
chirurgie |
|
radiotherapy |
radiothérapie |
|
chemotherapy |
chimiotherapie |
|
improvement |
amélioration |
|
length of survival |
durée de survie |
|
patient (-s) with |
malade de |
to |
carry out |
réaliser |
|
study |
étude |
to |
occur |
apparaître |
|
unlike |
contrairement à |
to |
pass through |
pénétrer |
|
bloodstream |
flux sanguin |
to |
bind to |
se fixer sur |
|
later |
plus tard |
|
single |
seul, unique |
|
low |
faible |
|
dose |
dose |
|
attached |
associé à |
to |
inject |
injecter |
|
cavity |
cavité |
|
drug |
drogue |
|
trial |
essai, tentative |
|
main reason |
raison principale |
to |
check |
vérifier |
|
tolerance |
tolérance |
|
adverse effect (-s) |
effets négatifs |
|
median |
moyen |
|
alive |
en vie |
|
evidence |
preuve |
|
Tumour specific
Analysis showed that the most
of the
radioactivity delivered by the drug had disappeared after 24 hours.
Any radiation that was left
was localised
to the tumour
cavity, suggesting the drug was binding to the tumour cells rather than
normal brain cells.
The drug also binds to other
types of
tumours and the researchers are planning further studies.
Study leader Dr Adam Mamelak,
a
neurosurgeon at
Cedars-Sinai Medical Center, said: "We're using TM-601 primarily as a
carrier to transport radioactive iodine to glioma cells, although there
are data to suggest that it may also slow down the growth of tumour
cells.
"If studies continue to
confirm this, we
may be able to
use it in conjunction with other treatments, such as chemotherapy,
because there may be a synergistic effect."
Ed Yong, cancer information
officer at
Cancer Research
UK, said: "Treating brain cancers with radioactive scorpion venom
sounds like science fiction.
"But this preliminary study
shows that
this approach is
safe and has potential. Now, larger trials are needed to work out how
effective it is.
"This study highlights the
varied and
ingenious approaches that scientists are using to improve cancer
treatments."
|
|
the most of |
l'essentiel de |
to |
be left |
rester |
to |
localise/localize |
localiser |
to |
plan |
prévoir |
|
study leader |
chef de projet |
|
neurosurgeon |
chirurgien en neurologie |
|
primarily |
d'abord |
to |
slow down |
ralentir |
|
growth |
croissance |
|
tumor cell (-s) |
cellule cancéreuse |
|
in conjunction with |
conjointement avec |
|
synergistic |
synergétique |
|
effect |
effet |
|
information officer |
chargé de l'information |
to |
treat |
traiter |
|
preliminary |
préliminaie |
|
approach |
approche |
|
safe |
sûr |
to |
have potential |
avoir du potentiel |
|
large |
vaste, étendu |
to |
be needed |
être nécessaire |
to |
work out |
établir |
to |
highlight |
éclairer |
|
varied |
varié |
|
ingenious |
ingénieux |
|